Women of childbearing age who inhale second-hand tobacco smoke even before conception may put their future babies at risk of impaired brain development, if the results of an animal study by scientists at Duke Health are found to apply to humans.
Using rats in experiments carefully designed to mimic the second-hand smoke exposures that humans encounter, this study is the first to show that exposure to second-hand smoke before conception is potentially damaging.
The researchers found that the chemical components of tobacco smoke affect fetal brain development throughout pregnancy.
The smoke exposure damages regions of the brain involved in learning, memory and emotional responses.
“This finding has important implications for public health, because it reinforces the need to avoid secondhand smoke exposure not only during pregnancy, but also in the period prior to conception, or generally for women of childbearing age,” said Theodore Slotkin, Ph.D., professor in Duke’s Department Pharmacology & Cancer Biology.
Although the impact of second-hand smoke was greatest with exposures occurring in late gestation, damage to the fetuses’ neuro-development was found even when the mothers were exposed only before conception.
Slotkin and colleagues, publishing in the January issue of the journal “Toxicological Sciences,” simulated secondhand smoke exposure by capturing and extracting the chemical compounds of tobacco smoke and administering the solution through implanted pumps in the laboratory animals.
Groups of female rats received the tobacco smoke extract during one of three periods: before mating, early gestation or late gestation.
The researchers then studied the offspring starting in early adolescence and into adulthood, focusing on brain regions that are known to be adversely affected by nicotine and tobacco smoke.
The researchers found that exposure to tobacco smoke extract in all three of the study periods resulted in the offspring having impaired function of the cholinergic brain circuits that govern learning and memory, and of the serotonin circuits that affect mood and emotional behavior.
It is not known how the smoke exposure damages fetal brain development prior to pregnancy. The researchers said more study is needed, but potential causes include the lingering effects of some of the smoke components, which can remain in the body for several days after exposure.
They also suggested that the chemicals might change the mother rat’s metabolism or hormonal status, or they could be causing an epigenetic alteration in the egg, which affects the activity of genes that control brain function.
An earlier study from the same team found a substantial portion of the tobacco smoke effect resulted from the nicotine in the smoke. That finding suggests that e-cigarettes could also represent a significant hazard for women of childbearing age.